Trauma and Neurocritical Care
Guidelines
- Eastern Association for the Surgery of Trauma (EAST): This collection of practice management guidelines cover a wide range of trauma and emergency general surgery topics, focusing on best practices for managing various injuries and conditions in adults. Key areas include the evaluation and management of blunt and penetrating trauma, antibiotic prophylaxis in surgical settings, and interventions for specific populations such as the elderly and pediatric patients. The recommendations aim to improve patient outcomes through evidence-based approaches and standardized care protocols.
- Brain Trauma Foundation Guidelines: This collection of guidelines address the comprehensive management of traumatic brain injury (TBI) across various contexts, including pediatric and adult populations. They provide evidence-based recommendations for prehospital care, surgical interventions, and prognosis assessment, emphasizing the importance of timely and effective treatment. Specific protocols for combat-related head trauma and the use of intracranial pressure monitoring are also highlighted to enhance patient outcomes in severe TBI cases.
- Neurocritical Care Society Guidelines: The Neurocritical Care Society provides a comprehensive set of evidence-based guidelines addressing various critical conditions, including traumatic brain injury, intracerebral hemorrhage, and spinal cord injuries. These guidelines cover neuroprognostication, seizure prophylaxis, and management strategies, ensuring healthcare professionals have the necessary tools to optimize patient outcomes in neurocritical care settings. Key topics also include targeted temperature management, treatment of cerebral edema, and protocols for managing specific complications like venous thrombosis and status epilepticus.
- 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association (Stroke 2022)
- 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association (Stroke 2023)
Blood Transfusion and Bleeding Management
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (Lancet 2010)
- Prehospital Tranexamic Acid for Severe Trauma (NEJM 2023)
- Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion (JAMA 2023)
- Management of Trauma Induced Coagulopathy with Thrombelastography (Crit Care Clin. 2017)
- The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition (Crit Care. 2023)
- Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage (AJHP 2023)
Venous Thromboembolism Prophylaxis
- American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Protocol for inpatient venous thromboembolism prophylaxis after trauma (J Trauma Acute Care Surg. 2022)
- A prospective study of venous thromboembolism after major trauma (N Engl J Med 1994)
- Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture (N Engl J Med 2023)
Traumatic Brain Injury
- Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial (Lancet 2019)
- Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate-Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society (Neurocrit Care 2024)
- Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury (JAMA Netw Open. 2022)
- Hypertonic Saline Versus Other Intracranial-Pressure-Lowering Agents for Patients with Acute Traumatic Brain Injury: A Systematic Review and Meta-analysis. (Neurocrit Care. 2023)
Surgical Prophylaxis
- American Academy of Orthopaedic Surgeons. Prevention of Surgical Site Infections After Major Extremity Trauma Evidence-Based Clinical Practice Guideline. (2022)
- Effect of pharmacist care on clinical outcomes and therapy optimization in perioperative settings: A systematic review (AJHP 2024)
- Interventions to improve compliance with guidelines on surgical prophylaxis (AJHP 2005)
- Weighing in on antibiotic dosing for surgical site prophylaxis (AJHP 2020)
- Cost-effectiveness analysis of six strategies for cardiovascular surgery prophylaxis in patients labeled penicillin allergic (AJHP 2000)
Guidelines
- Eastern Association for the Surgery of Trauma (EAST): This collection of practice management guidelines cover a wide range of trauma and emergency general surgery topics, focusing on best practices for managing various injuries and conditions in adults. Key areas include the evaluation and management of blunt and penetrating trauma, antibiotic prophylaxis in surgical settings, and interventions for specific populations such as the elderly and pediatric patients. The recommendations aim to improve patient outcomes through evidence-based approaches and standardized care protocols.
- Brain Trauma Foundation Guidelines: This collection of guidelines address the comprehensive management of traumatic brain injury (TBI) across various contexts, including pediatric and adult populations. They provide evidence-based recommendations for prehospital care, surgical interventions, and prognosis assessment, emphasizing the importance of timely and effective treatment. Specific protocols for combat-related head trauma and the use of intracranial pressure monitoring are also highlighted to enhance patient outcomes in severe TBI cases.
- Neurocritical Care Society Guidelines: The Neurocritical Care Society provides a comprehensive set of evidence-based guidelines addressing various critical conditions, including traumatic brain injury, intracerebral hemorrhage, and spinal cord injuries. These guidelines cover neuroprognostication, seizure prophylaxis, and management strategies, ensuring healthcare professionals have the necessary tools to optimize patient outcomes in neurocritical care settings. Key topics also include targeted temperature management, treatment of cerebral edema, and protocols for managing specific complications like venous thrombosis and status epilepticus.
- 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association (Stroke 2022)
- 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association (Stroke 2023)
Blood Transfusion and Bleeding Management
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (Lancet 2010)
- Prehospital Tranexamic Acid for Severe Trauma (NEJM 2023)
- Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion (JAMA 2023)
- Management of Trauma Induced Coagulopathy with Thrombelastography (Crit Care Clin. 2017)
- The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition (Crit Care. 2023)
- Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage (AJHP 2023)
Venous Thromboembolism Prophylaxis
- American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Protocol for inpatient venous thromboembolism prophylaxis after trauma (J Trauma Acute Care Surg. 2022)
- A prospective study of venous thromboembolism after major trauma (N Engl J Med 1994)
- Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture (N Engl J Med 2023)
Traumatic Brain Injury
- Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial (Lancet 2019)
- Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate-Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society (Neurocrit Care 2024)
- Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury (JAMA Netw Open. 2022)
- Hypertonic Saline Versus Other Intracranial-Pressure-Lowering Agents for Patients with Acute Traumatic Brain Injury: A Systematic Review and Meta-analysis. (Neurocrit Care. 2023)
Surgical Prophylaxis
- American Academy of Orthopaedic Surgeons. Prevention of Surgical Site Infections After Major Extremity Trauma Evidence-Based Clinical Practice Guideline. (2022)
- Effect of pharmacist care on clinical outcomes and therapy optimization in perioperative settings: A systematic review (AJHP 2024)
- Interventions to improve compliance with guidelines on surgical prophylaxis (AJHP 2005)
- Weighing in on antibiotic dosing for surgical site prophylaxis (AJHP 2020)
- Cost-effectiveness analysis of six strategies for cardiovascular surgery prophylaxis in patients labeled penicillin allergic (AJHP 2000)
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