Toxicology

Guidelines, Consensus Statements and Organization Resources 

• The American Academy of Clinical Toxicology provides essential guidelines and position statements on various aspects of toxicology and emergency response. They cover topics such as reporting standards for drug-induced QT prolongation, occupational safety for responders to fentanyl exposure, and the use of intravenous lipid emulsion therapy for poisoning. Additional statements address the management of poisonings, including the roles of whole bowel irrigation, activated charcoal, and naloxone, while systematic reviews assess the efficacy and safety of these treatments, as well as their impact on laboratory analyses.
• The EXtracoporeal TReatments In Poisoning Workgroup (EXTRIP), provides recommendations on extracorporeal treatments for various types of poisoning, providing systematic reviews and recommendations from the EXTRIP Workgroup for specific toxins, including tricyclic antidepressants, acetaminophen, baclofen, and others. Each document outlines the clinical effectiveness and safety of extracorporeal interventions, guiding healthcare professionals in managing toxic exposures. Additionally, reporting guidelines are included to standardize the documentation of case studies related to these treatments, enhancing the overall quality of clinical data in toxicology.
• Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement (JAMA NetW Open 2023)
• Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults (Crit Care Med. 2017)
• 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care (Circulation 2023)
• Wilderness Medical Society Practice Guidelines for the Treatment of Pitviper Envenomations in the United States and Canada (Wilderness & Environmental Medicine 2015)

Articles 

• Extracorporeal Removal of Poisons and Toxins (Clin J Am Soc Nephrol. 2019)
• Antidotes for toxicological emergencies: A practical review (AJHP 2012)
• Review of North American pit viper antivenoms (AJHP 2020)
• Is Two Better Than Three? A Systematic Review of Two-bag Intravenous N-acetylcysteine Regimens for Acetaminophen Poisoning (West J Emerg Med 2023)