Sepsis
Guidelines
- Surviving Sepsis guidelines: International guidelines for management of sepsis and septic shock (Crit Care Med 2021)
Fluids
- Albumin replacement in pts with severe sepsis or septic shock (ALBIOS) (New Engl J Med 2014)
- Restriction of intravenous fluid in ICU patients with septic shock (CLASSIC) (New Engl J Med 2022)
- Early restrictive or liberal fluid management for sepsis-induced hypotension (CLOVERS) (New Engl J Med 2023)
- A comparison of albumin and saline for fluid resuscitation in the intensive care unit (SAFE) (New Engl J Med 2004)
- Hydroxyethyl starch 130/0.42 vs Ringer’s acetate in severe sepsis (6S) (New Engl J Med 2012)
- Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension (JAMA 2017)
Vasopressors
- Comparison of dopamine and norepinephrine in the treatment of shock (SOAP II) (New Engl J Med 2010)
- Vasopressin vs norepinephrine infusion in patients with septic shock (VAST) (New Engl J Med 2008)
- Angiotensin II for the treatment of vasodilatory shock (ATHOS-3) (New Engl J Med 2017)
- Putting midodrine on the MAP: An approach to liberation from intravenous vasopressors in vasodilatory shock (AJHP 2022)
Corticosteroids
- Hydrocortisone therapy for patients with septic shock (CORTICUS) (New Engl J Med 2008)
- Adjunctive glucocorticoid therapy in patients with septic shock (ADRENAL) (New Engl J Med 2018)
- Hydrocortisone plus fludrocortisone for adults with septic shock (APROCCHSS) (New Engl J Med 2018)
- Effect of fixed-dose hydrocortisone on vasopressor dose and mean arterial pressure in obese and nonobese patients with septic shock (AJHP 2022)
Refractory Sepsis
- Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis (VICTAS) (JAMA 2021)
- Intravenous vitamin C in adults with sepsis in the intensive care unit (LOVIT) (New Engl J Med 2022)
- Effect of levocarnitine vs placebo as adjunctive treatment for septic shock (RACE) (JAMA 2018)
- Unanswered questions on the use of hydrocortisone, ascorbic acid, and thiamine therapy in sepsis and septic shock (AJHP 2022)
Goal Directed Therapy
- Early goal-directed therapy in the treatment of severe sepsis and septic shock (New Engl J Med 2001)
- Early, goal-directed therapy for septic shock – a patient-level meta-analysis (PRISM) (New Engl J Med 2017)
- A randomized trial of protocol-based care for early septic shock (PROCESS) (New Engl J Med 2014)
- Trial of early, goal-directed resuscitation for septic shock (PROMISE) (New Engl J Med 2015)
- Goal-directed resuscitation for patients with early septic shock (ARISE) (New Engl J Med 2014)
Antimicrobials
- The timing of early antibiotics and hospital mortality in sepsis (Am J Respir Crit Care Med 2017)
- Continuous vs intermittent meropenem administration in critically ill patients with sepsis (MERCY) (JAMA 2023)
- Procalcitonin for sepsis management: Implementation within an antimicrobial stewardship program (AJHP 2023)
Coagulopathy
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