9/6/2024

Amino Acid Products

Products Affected - Description

- Aminosyn-PF (sulfite-free) injection, ICU Medical, 10%, 1000 mL flexible container, 6 count, NDC 00990-4179-05
- Aminosyn-PF (sulfite-free) injection, ICU Medical, 7%, 500 mL flexible container, 12 count, NDC 00990-4178-03
- Clinisol (sulfite-free) injection, Baxter, 15%, 500 mL flexible container, 24 count, NDC 00338-0502-03

Reason for the Shortage

- Baxter has most amino acid presentations available. Prosol is on shortage due to manufacturing delays.
- BBraun has Plenamine and TrophAmine available. The company has discontinued FreAmine III and ProcalAmine.
- ICU Medical has Aminosyn on shortage due to manufacturing delays.

Available Products

- Aminosyn II (sulfite-free) injection, ICU Medical, 10%, 2000 mL flexible container, 6 count, NDC 00990-7172-17
- Aminosyn II (sulfite-free) injection, ICU Medical, 15%, 2000 mL flexible container, 6 count, NDC 00990-7171-17
- Clinisol (sulfite-free) injection, Baxter, 15%, 2000 mL flexible container, 6 count, NDC 00338-0502-06
- Plenamine injection, BBraun, 15%, 1000 mL flexible container, 8 count, NDC 00264-4500-00
- Plenamine injection, BBraun, 15%, 2000 mL flexible container, 8 count, NDC 00264-4500-05
- Premasol (sulfite-free) injection, Baxter, 10%, 1000 mL flexible container, 12 count, NDC 00338-1130-04
- Premasol (sulfite-free) injection, Baxter, 10%, 2000 mL flexible container, 6 count, NDC 00338-1130-06
- Premasol (sulfite-free) injection, Baxter, 10%, 500 mL flexible container, 24 count, NDC 00338-1130-03
- Prosol (sulfite-free) injection, Baxter, 20%, 2000 mL flexible container, 6 count, NDC 00338-0499-06
- Travasol injection, Baxter, 10%, 1000 mL flexible container, 12 count, NDC 00338-0644-04
- Travasol injection, Baxter, 10%, 2000 mL flexible container, NDC 00338-0644-06
- Travasol injection, Baxter, 10%, 500 mL flexible container, 6 count, NDC 00338-0644-03
- TrophAmine injection, BBraun, 10%, 500 mL plastic container, 12 count, NDC 00264-1933-10

Estimated Resupply Dates

- Baxter has 15% Clinisol 500 mL containers available in limited supply.
- ICU Medical has 7% Aminosyn-PF in 500 mL and 10% Aminosyn-PF in 1,000 mL containers on back order and the company cannot estimate a release date.

Implications for Patient Care

- Travasol product information now includes dosage information for pediatric patients. Travasol product information can be found at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8543b5be-0f43-4891-9e56-d7c39fe839b5. A comparison chart of Premasol and Travasol is available at https://www.nutritioncare.org/uploadedFiles/Documents/Guidelines_and_Clinical_Resources/Comparison%20Chart%20of%20Premasol%20and%20Travasol.pdf

Safety

- ASPEN provides recommendations for managing shortages of parenteral nutrition products. See their website for more details.

Updated

Updated September 6, 2024 by Leslie Jensen, PharmD, Drug Information Specialist. Created May 21, 2019 by Leslie Jensen, PharmD, Drug Information Specialist. © 2024, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

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